43,252,003,274,489,856,000 (Forty three quintillion ...)

The Rubik's Cube is advertized as having billions of possible permutations, but that is only because it was thought that the general public would be unable to comprehend the actual number: 43,252,003,274,489,856,000. If you had a Rubik's Cube for each of its possible permutations and laid them side by side, they would stretch for 261 light years!